Two months after the start of the route, it was announced that the airline will daily connect Mendoza province with Central America, the Caribbean and North America through the Hub of the Americas in Panama. From July 16th, the CM 421 flight will depart daily from Mendoza at 1:34 a. m., arriving to Tocumen International Airport in Panama City at 6:30 a. m. The return flight, CM 420 will depart at 3:40 p. m. from Panama, arriving at 12:21 a. m. to "El Plumerillo" Airport. Mendoza is the fourth Copa Airlines route in Argentina, together with Buenos Aires, Córdoba and Rosario.

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